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Home / General / Anti-Allergic / KESTINE
Anti-Allergic

KESTINE

Ebastine is a H1 antihistamine with low potential for causing drowsiness. It does not penetrate the blood–brain barrier to a significant amount and thus combines an effective block of the H1 receptor in peripheral tissue with a low incidence of central side effects. It is indicated mainly for allergic rhinitis and chronic idiopathic* urticaria*.

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General Info

Generic Name:

Ebastine

Therapeutic Category:

Anti-allergy

Pharmacological Class:

Selective H1 antagonist (Second Generation)

Composition:

Kestine 10                Each film coated tablet contains Ebastine BP 10 mg.

Kestine 20          Each film coated tablet contains Ebastine BP 20 mg.

Pregnancy Category:

B

Presentation:

Available in the pack size as 10 tablets X 10 blisters

Presentation:

Available in the pack size as 10 tablets X 10 blisters

Indications:
    • Allergic Rhinitis
    • Pruritus
    • Dermographic Urticaria*
    • Idiopathic Chronic Urticaria
    • Acquired cold urticaria
Dosage:

Route of administration: Oral

Adult: 10-20 mg once daily.

Child: >6 years: 5 mg once daily.

Pharmacokinetics:

Absorption: Rapidly absorbed after oral administration

Metabolism: Hepatic

Protein binding: Approximately 95%

Route of elimination: Renal

Half-life: 15-19 hours

Adverse Effects:

Common side effects are: Headache, Dry mouth, Drowsiness, Pharyngitis, Abdominal pain, Dyspepsia, Asthenia*, Epistaxis*, Rhinitis, Sinusitis, Nausea, and Insomnia

It does not have systemic anticholinergic side effects and does no cause sedation.

Contraindications:

KESTINE is contraindicated in the following situations:

  • Hypersensitivity to Ebastine or any of its ingredients
  • Cardiac arrhythmia
Precautions:
    • Hypokalemia*
    • Hepatic impairment
    •  Renal impairment
Drug Interactions:

Idiopathic: Relating to or denoting any disease or condition which arises spontaneously or for which the cause is unknown.

Urticaria: A kind of skin rash with red, raised, itchy bumps.

Prodrug: A medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.

Dermographic Urticaria: Also known as dermographism, dermatographism or “skin writing; is an exaggerated wealing tendency when the skin is stroked.

Asthenia: Abnormal physical weakness or lack of energy.

Epistaxis: Bleeding from the nostril, nasal cavity, or nasopharynx.

Hypokalemia: The condition when  blood’s potassium levels are too low.

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