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Home / General / Anti-Tussive / COFSY-D
Anti-Tussive

COFSY-D

Levodropropizine is a cough suppressant. It is the levo isomer of dropropizine. It acts as a peripheral antitussive, with no action in the central nervous system.

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General Info

Generic Name:

Levodropropizine

Therapeutic Category:

Antitussive

Pharmacological Class:

Cough Suppressant

Composition:

Each 5 ml contains Levodropropizine BP 30 mg.

Pregnancy Category:

D

Presentation:

100 ml bottle with a measuring cap

Mechanism of Action:

It reduces cough by:

  • Peripheral anti-tussive drugs act on chemical and mechanical receptors mainly located in the larynx and trachea lacking effects on the central nervous system, which make them more tolerable.
  • Interfering with stimulus activation of peripheral endings of sensory nerves.
  • Acts as a peripheral antitussive, with no action in the CNS
  • Does not cause side effects such as constipation or respiratory depression which can be produced by opioid antitussives such as codeine and its derivatives.
Indications:
  • Dry irritating cough
Dosage:

Route of administration: Oral

As a cough suppressant (Adults): 60 mg of COFSY-D, thrice daily. The duration should not exceed more than seven days.

As a cough suppressant (Pediatrics):

For children >2 years: 1 mg/kg, thrice daily.

For children >12 years: consider administration of 60 mg of COFSY-D, thrice daily.

The duration should not exceed more than seven days.

Pharmacokinetics:

Absorption: Rapidly absorbed in GIT

Protein binding: Approximately 11-14%

Route of elimination: Renal

Adverse Effects:

The symptomatic adverse reactions produced by COFSY-D are more or less tolerable. These include:

Weakness, Dizziness, Headache, Drowsiness, Fatigue, Nausea, Vomiting, Diarrhea, Palpitation, Heart burn, dizziness, Weakness.

Contraindication:

COFSY-D is contraindicated in the following situations:

  • Excessive mucus discharge and limited muco-ciliary function.
  • Severe liver impairment.
  • Should not be given in pregnant and lactating mothers
Interactions:
  • May interact with alcohols, sedatives, hypnotics and anti-histamines.

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