| Generic Name: |
Drotaverine HCl
|
| Therapeutic Category: |
Antispasmodic
|
| Pharmacological Class: |
Cholinergic Muscarinic Antagonist
|
| Composition: |
Dove 40
Each film coated tablet contains Drotaverine HCl 40mg.
Dove 80
Each film coated tablet contains Drotaverine HCl 80mg.
|
| Pregnancy Category: |
C
|
| Presentation: |
Available in the pack size as 10 tablets X 20 blisters
|
| Mechanism of Action: |
- Cyclic AMP (cAMP) is a second messenger to regulate a large number of key processes.
- Phosphodiesterase (PDE) hydrolyses cAMP, thus decreasing its concentration in the cells.
- cAMP and Ca++ imbalance results in smooth muscle spasm and pain.
- Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle.
- Drotaverine acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.
- It has a rapid and direct action on the smooth muscle.
|
| Indications: |
- Intestinal and Biliary renal colics*
- Irritable Bowel Syndrome(IBS)
- Uterine Spasm
|
| Dosage: |
Route of administration: Oral
Children more than 6 years: 40 mg orally 3 times a day tid.
No data regarding the Pediatric dosage details of Drotaverine is available.
The medication can be taken with or without food.
|
| Pharmacokinetics : |
Absorption: Rapidly absorbed from the GI tract
Protein binding: Approximately 80-95%
Metabolism: Hepatic
Route of elimination: >50% in urine and ~30% in bile
Half-life: 7-12 hours
|
| Adverse Effects: |
Dizziness, Vertigo, Headache, Nausea, Vomiting, Palpitation, Constipation, Insomnia, Dry mouth, Hypotension
|
| Contraindications: |
DOVE is contraindicated in the following conditions:
- Cardiac dysfunction
- Renal insufficiency
- Hepatic insufficiency
|
| Interactions: |
No data regarding the interactions of Drotaverine was found.
|
| Terminologies: |
Colic: severe pain in the abdomen caused by wind or obstruction in the intestines.
|
